Tell her to call Covenant Transport. They have a terminal in Indianapolis and a limited number of local dedicated jobs out of Indy. They might not have any current availabilities, but its worth a try. Be sure & tell her to be firm with the recruiters on the phone, tell them she will NOT come to orientation unless they guarantee her, in writing, that she will be placed on the Indy Regional fleet. (Otherwise, they're likely to try and give her the run-around).
If that doesnt pan out here are some local/linehaul companies she could apply with:
Fed Ex Freight:
Most of your local/linehaul jobs have positions where she'd be home nightly, making local pickups and drops. Or, they might require her to do some linehaul work for a while first, but it's most likely she'd only be gone 1-2 nights at a time.
Also, check around at local grocery stores. I have no idea what the names of grocery stores are in Indiana, but I am sure she could ask the managers at the stores, and find out the location of the warehouse, or look it up online. She'd need to apply directly at the warehouse, for a driving job.
She might also try contacting the local Teamsters Union office; many local trucking jobs are union (especially grocery warehouse jobs) and she would have access to more job opportunities as a member.
If she's willing to try car-hauling, she could get a job with Allied Auto Group. They will train; and I am fairly certain they only require 1 year of safe driving experience. I did it (and I am a female- it doesn't require a lot of strength per se, just agility, quick thinking and no fear of heights :). It pays quite well and is a union job also.
Best of luck to your mom :)