Since I don't know what kind of comedy you prefer here is a bit of everything I enjoyed :) ::
Ouran High School Host Club (comedy, high school, bishounen, random)
Ouran High is a school for the extremely wealthy or, in Haruhi's case, the extremely talented. But no amount of talent will help when Haruhi accidentally drops an eight million yen vase in a music room. The vase was the property of Ouran High School Host Club, a group of attractive young men who, for a fee, provide their time and affections for their lovesick clientele: the female students. Fascinated by this strange new specimen, a poor and clumsy commoner, they force Haruhi to work for them until the debt is repaid; but they get a lot more than they bargained for...
Azumanga Daioh (comedy, slice of life, random, high school)
Ten-year-old genius Chiyo, animal-loving Sakaki, loudmouth Tomo, athletic Kagura, weight-conscious Yomi and dim-witted Osaka are six friends who share laughs, good times, and a high school homeroom. With scary (and sometimes perverted) teachers, school festivals, penguin suits and general hilarity abounding, you can be sure that there's never a dull day in the life of one of these students!
Tengen Toppa Gurren Langann (comedy, mecha, shounen, sci fi)
Simon lives a boring life in the underground village of Jeeha, where his main job day in and day out is to dig tunnels. His close friend Kamina, however, longs to bust out of their oppressive existence and reach the surface world where open skies and adventure await! One day, during his usual digs, Simon discovers a robot with a big face buried amongst the rocks. No sooner has he shown Kamina his mysterious find when two beings from the surface crash land into Jeeha Village - one is a gun-toting woman calling herself Yoko and the other is a terrifying mecha piloted by a Beastman! Seeing their chance to escape village drudgery, Kamina rallies Simon and Yoko to defeat the invader using their new robot, Lagann. However, upon breaking out onto the surface world, Simon, Kamina, and Yoko encounter enemies more powerful than they could have envisioned. Their fight for adventure just turned into a war for the survival of the human race - will their lust for freedom hold out against such terrible odds?
Sayonara Zetsubou Sensei (comedy, satire, drama, parody)
Life is simply not worth living for down and out school teacher Itoshiki Nozomu. He has no hope of progress, no prospect of promotion, no chance at happiness… he is in despair! Even his name spells 'zetsubou' – 'despair', when compressed. But when the time comes to end it all, Itoshiki's attempted suicide on the first day of the new school year is foiled by relentlessly positive Fuura Kafuka. This saves Itoshiki long enough to meet his new class, and the quirky range of students under his care. Will Itoshiki Nozomu depress his students with his anguish? Or will Fuura show Zetsubou-sensei the joys of life and hope?
Gintama (comedy, samurai, random, episodic, parody)
In Gintoki's Japan, the arrival of the various space races known collectively as the Amanto ended the era of the samurai. The Amanto's highly advanced technology resulted in total conquest and a severe economic shift. Now, former samurai such as Gintoki scrape together whatever livelihood they can. Gintoki's profession of choice is that of a yorozuya: he'll complete any job for money. However, he’s unmotivated; and spending most of the day on the couch with the latest issue of Jump and a carton of Strawberry Milk is his preferred pastime. It turns out that his new unpaid employees, Shinpachi and Kagura, are going to interfere with his pastime even more than with his "work"! Of course, none of this means he has really given up on his samurai ideologies!
Yakitate! Japan (comedy, random)
Dimwitted Azuma Kazuma is a young man with a dream -- to create a bread worthy of the name "Japan", made by the Japanese people, for the Japanese people! With hefty bread-making skills, hands that have an uncanny warmth to help dough ferment, and will power like no other, Kazuma must put his delicious creations to the test as he struggles to become employed at the prestigious Pantasia bakery, for fame and glory! Yeast, beware... Kazuma is in the kitchen!
The Melancholy of Haruhi Suzumiya (comedy, school life, drama)
The eccentric Suzumiya Haruhi wants nothing more than to meet aliens, time travelers and espers… but she’ll have to settle for the everyday Kyon instead! Along with the mysterious Itsuki and the vacant Mikuru, the duo forms the SOS Brigade – a club whose mission is to discover the mysteries of the world. Armed with a razor sharp wit and a skill for manipulation, Haruhi will stop at nothing to have fun at all costs, even at the expense of Mikuru’s dignity!
Genshiken! (comedy, otaku, parody)
Ever wanted to join an anime club but felt its geekiness would hurt your reputation? Sasahara feels your pain. Genshiken, the Society for the Study of Modern Visual Culture, is an organization of college otaku obsessed with anime, manga and video games. Their daily activities include holding impromptu cosplay photo shoots, braving the crowds and avoiding injury at doujinshi conventions, and tolerating harassment by Saki, a girl irked by her boyfriend's otaku-ness! It's a perfect match for Sasahara's interests, so why is it so difficult for him to join?
Hope this helps :D
Answered By: ♫Krystal♫ - 10/3/2009